DC-Chol has also been broadly Utilized in the synthesis of liposomes with the delivery of siRNA, DNA, and chemotherapeutic brokers into cells and mice.
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This substance can be a structure drug and isn't prohibited in several countries of the planet as a means for scientific research in special laboratories.
Tolerance and Dependence : Continual this compound administration in mice induced negligible tolerance and dependence when compared with morphine
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Exhibited outstanding potency when compared to morphine and oxycodone, sustaining efficiency on recurring administration
Standardize Agonist Publicity Instances : this compound’s sluggish dissociation kinetics need prolonged observation durations to capture whole β-arrestin recruitment .
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It doesn't significantly induce βarrestin2 recruitment on the MOR at concentrations down below 10 μM, suggesting its mechanism of action largely will involve signaling by means of G proteins rather then βarrestin2 pathways.
Substitution: Nucleophilic substitution reactions may be executed working with reagents like sodium methoxide or potassium tert-butoxide.
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